Drug interactions
Erythromycin + Paromomycin
Severity: Minor
Erythromycin and Paromomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral paromomycin is minimally absorbed, so a P-glycoprotein-mediated increase in its systemic levels is unlikely to be clinically significant. No meaningful clinical interaction has been established.
What this interaction means in plain words
Erythromycin and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erythromycin belongs to Anti Bacterial; Paromomycin belongs to Anti Bacterial.
Why it happens
Theoretical P-glycoprotein inhibition by erythromycin; clinically irrelevant given negligible oral absorption of paromomycin.
What to do
No specific action is needed. Monitor renal function only if there is significant renal impairment or a damaged intestinal mucosa.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Erythromycin with Paromomycin?
MediHelp rates the interaction as minor. Erythromycin and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral paromomycin is minimally absorbed, so a P-glycoprotein-mediated increase in its systemic levels is unlikely to be clinically significant. No meaningful clinical interaction has been established.
How serious is the interaction between Erythromycin and Paromomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed. Monitor renal function only if there is significant renal impairment or a damaged intestinal mucosa.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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