Drug interactions
Erythromycin + Pretomanid
Severity: Moderate
Erythromycin and Pretomanid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid-containing regimens are associated with hepatotoxicity, and erythromycin can also cause liver injury, particularly the estolate form. Combining them may add to hepatic risk.
What this interaction means in plain words
Erythromycin and Pretomanid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Pretomanid belongs to Anti Bacterial.
Why it happens
Additive hepatotoxic potential; no established pharmacokinetic mechanism.
What to do
Use an alternative antibiotic when feasible. If combined, monitor liver function tests regularly and stop therapy if hepatotoxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Pretomanid
Frequently asked questions
Can I take Erythromycin with Pretomanid?
MediHelp rates the interaction as moderate. Erythromycin and Pretomanid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pretomanid-containing regimens are associated with hepatotoxicity, and erythromycin can also cause liver injury, particularly the estolate form. Combining them may add to hepatic risk.
How serious is the interaction between Erythromycin and Pretomanid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic when feasible. If combined, monitor liver function tests regularly and stop therapy if hepatotoxicity develops.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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