Drug interactions
Erythromycin + Risperidone
Severity: Moderate
Erythromycin and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin may modestly raise risperidone exposure through P-glycoprotein inhibition, and both drugs can prolong the QT interval. Together they may increase the risk of QT prolongation and arrhythmia, especially with other risk factors.
What this interaction means in plain words
Erythromycin and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Risperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation plus possible P-glycoprotein inhibition by erythromycin increasing risperidone levels.
What to do
Obtain a baseline ECG and monitor QTc, and correct potassium and magnesium abnormalities. Consider an alternative antibiotic such as azithromycin if QT risk factors are present, or reduce the risperidone dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Erythromycin with Risperidone?
MediHelp rates the interaction as moderate. Erythromycin and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin may modestly raise risperidone exposure through P-glycoprotein inhibition, and both drugs can prolong the QT interval. Together they may increase the risk of QT prolongation and arrhythmia, especially with other risk factors.
How serious is the interaction between Erythromycin and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc, and correct potassium and magnesium abnormalities. Consider an alternative antibiotic such as azithromycin if QT risk factors are present, or reduce the risperidone dose if adverse effects appear.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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