Drug interactions
Erythromycin + Rucaparib
Severity: Minor
Erythromycin and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a moderate CYP3A4 inhibitor and can increase the exposure of CYP3A4 substrates such as erythromycin. The effect is usually modest, but erythromycin toxicity such as GI upset or QT prolongation could be more likely.
What this interaction means in plain words
Erythromycin and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erythromycin belongs to Anti Bacterial; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP3A4 and reduces erythromycin metabolism.
What to do
No routine dose change is needed. Monitor for erythromycin adverse effects, including gastrointestinal intolerance and palpitations.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Erythromycin with Rucaparib?
MediHelp rates the interaction as minor. Erythromycin and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a moderate CYP3A4 inhibitor and can increase the exposure of CYP3A4 substrates such as erythromycin. The effect is usually modest, but erythromycin toxicity such as GI upset or QT prolongation could be more likely.
How serious is the interaction between Erythromycin and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for erythromycin adverse effects, including gastrointestinal intolerance and palpitations.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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