Drug interactions
Erythromycin + Stiripentol
Severity: Minor
Erythromycin and Stiripentol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits CYP3A4 and P-glycoprotein and may induce CYP3A4, so erythromycin exposure may be altered unpredictably. The clinical significance is uncertain and probably modest.
What this interaction means in plain words
Erythromycin and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erythromycin belongs to Anti Bacterial; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol has mixed CYP3A4 inhibitory and inducing effects and inhibits P-glycoprotein efflux, which can change erythromycin concentrations.
What to do
No empirical dose change is needed. Monitor clinical response to erythromycin and for gastrointestinal or QT-related adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Erythromycin with Stiripentol?
MediHelp rates the interaction as minor. Erythromycin and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stiripentol inhibits CYP3A4 and P-glycoprotein and may induce CYP3A4, so erythromycin exposure may be altered unpredictably. The clinical significance is uncertain and probably modest.
How serious is the interaction between Erythromycin and Stiripentol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor clinical response to erythromycin and for gastrointestinal or QT-related adverse effects.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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