Drug interactions
Erythromycin + Temsirolimus
Severity: Moderate
Erythromycin and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin may increase exposure to temsirolimus and its active metabolite sirolimus, raising the risk of toxicities such as myelosuppression, mucositis and infection.
What this interaction means in plain words
Erythromycin and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Temsirolimus belongs to Oncology.
Why it happens
CYP3A4 inhibition by erythromycin reduces metabolism of temsirolimus and sirolimus.
What to do
Choose a non-interacting antibiotic where possible. If used together, monitor blood counts and toxicity and consider a temsirolimus dose reduction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Erythromycin with Temsirolimus?
MediHelp rates the interaction as moderate. Erythromycin and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin may increase exposure to temsirolimus and its active metabolite sirolimus, raising the risk of toxicities such as myelosuppression, mucositis and infection.
How serious is the interaction between Erythromycin and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose a non-interacting antibiotic where possible. If used together, monitor blood counts and toxicity and consider a temsirolimus dose reduction.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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