Drug interactions
Erythromycin + Valbenazine
Severity: Moderate
Erythromycin and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs may prolong the QT interval, and erythromycin may raise exposure to valbenazine's active metabolite via CYP3A4 inhibition. This increases the risk of QT-related arrhythmia.
What this interaction means in plain words
Erythromycin and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Valbenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation plus CYP3A4 inhibition raising valbenazine exposure.
What to do
Consider an alternative antibiotic. If combined, monitor ECG and electrolytes and consider a reduced valbenazine dose per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Erythromycin with Valbenazine?
MediHelp rates the interaction as moderate. Erythromycin and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs may prolong the QT interval, and erythromycin may raise exposure to valbenazine's active metabolite via CYP3A4 inhibition. This increases the risk of QT-related arrhythmia.
How serious is the interaction between Erythromycin and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antibiotic. If combined, monitor ECG and electrolytes and consider a reduced valbenazine dose per labeling.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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