Drug interactions
Erythromycin + Zonisamide
Severity: Minor
Erythromycin and Zonisamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zonisamide is partly metabolized by CYP3A4, so erythromycin may raise its concentrations. This could increase dose-related adverse effects such as somnolence, dizziness and cognitive slowing.
What this interaction means in plain words
Erythromycin and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erythromycin belongs to Anti Bacterial; Zonisamide belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition by erythromycin reduces zonisamide metabolism.
What to do
Monitor for sedation, dizziness and other zonisamide adverse effects during the antibiotic course; adjust dose if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
Frequently asked questions
Can I take Erythromycin with Zonisamide?
MediHelp rates the interaction as minor. Erythromycin and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zonisamide is partly metabolized by CYP3A4, so erythromycin may raise its concentrations. This could increase dose-related adverse effects such as somnolence, dizziness and cognitive slowing.
How serious is the interaction between Erythromycin and Zonisamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness and other zonisamide adverse effects during the antibiotic course; adjust dose if symptoms occur.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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