Drug interactions
Erythromycin base + Leuprolide
Severity: Moderate
Erythromycin base and Leuprolide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin is a recognized cause of QT prolongation and torsades de pointes. Leuprolide may add to this effect, increasing arrhythmia risk especially with electrolyte abnormalities or heart disease.
What this interaction means in plain words
Erythromycin base and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Consider a non-QT-prolonging antibiotic when feasible. Otherwise check ECG and electrolytes and keep the course short.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Frequently asked questions
Can I take Erythromycin base with Leuprolide?
MediHelp rates the interaction as moderate. Erythromycin base and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin is a recognized cause of QT prolongation and torsades de pointes. Leuprolide may add to this effect, increasing arrhythmia risk especially with electrolyte abnormalities or heart disease.
How serious is the interaction between Erythromycin base and Leuprolide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a non-QT-prolonging antibiotic when feasible. Otherwise check ECG and electrolytes and keep the course short.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
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