Drug interactions
Erythromycin lactobionate + Fludrocortisone
Severity: Minor
Erythromycin lactobionate and Fludrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4 and may modestly raise corticosteroid exposure, which could increase fluid retention, hypokalemia and hypertension with fludrocortisone. The reverse effect on erythromycin is not established.
What this interaction means in plain words
Erythromycin lactobionate and Fludrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erythromycin lactobionate belongs to Anti Bacterial; Fludrocortisone belongs to Endocrine.
Why it happens
Erythromycin inhibits CYP3A4, which contributes to the metabolism of fludrocortisone.
What to do
Monitor blood pressure, edema and serum potassium during intravenous erythromycin. Reduce the fludrocortisone dose if mineralocorticoid excess develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fludrocortisone
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Erythromycin lactobionate with Fludrocortisone?
MediHelp rates the interaction as minor. Erythromycin lactobionate and Fludrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erythromycin inhibits CYP3A4 and may modestly raise corticosteroid exposure, which could increase fluid retention, hypokalemia and hypertension with fludrocortisone. The reverse effect on erythromycin is not established.
How serious is the interaction between Erythromycin lactobionate and Fludrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, edema and serum potassium during intravenous erythromycin. Reduce the fludrocortisone dose if mineralocorticoid excess develops.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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