Drug interactions
Erythromycin lactobionate + Nifedipine
Severity: Moderate
Erythromycin lactobionate and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin is a CYP3A4 inhibitor that raises nifedipine concentrations, which may cause hypotension, flushing and edema. The legacy direction is reversed, since nifedipine does not meaningfully raise erythromycin.
What this interaction means in plain words
Erythromycin lactobionate and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin lactobionate belongs to Anti Bacterial; Nifedipine belongs to Cardiovascular.
Why it happens
Erythromycin inhibits CYP3A4-mediated first-pass and hepatic metabolism of nifedipine.
What to do
Monitor blood pressure and edema during erythromycin therapy. Reduce the nifedipine dose if hypotension occurs, or consider azithromycin as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Erythromycin lactobionate with Nifedipine?
MediHelp rates the interaction as moderate. Erythromycin lactobionate and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous erythromycin is a CYP3A4 inhibitor that raises nifedipine concentrations, which may cause hypotension, flushing and edema. The legacy direction is reversed, since nifedipine does not meaningfully raise erythromycin.
How serious is the interaction between Erythromycin lactobionate and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema during erythromycin therapy. Reduce the nifedipine dose if hypotension occurs, or consider azithromycin as an alternative.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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