Drug interactions
Erythromycin lactobionate + Paroxetine
Severity: Moderate
Erythromycin lactobionate and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin prolongs the QT interval and can cause torsades de pointes, and peak concentrations are higher with IV use. Paroxetine has a minor QT effect, so combined use may add to the risk, especially with other risk factors.
What this interaction means in plain words
Erythromycin lactobionate and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin lactobionate belongs to Anti Bacterial; Paroxetine belongs to Central Nervous System.
Why it happens
Additive QT prolongation; erythromycin also inhibits CYP3A4, which has only a minor role in paroxetine clearance.
What to do
Consider an alternative antibiotic in patients with QT risk factors. If combined, monitor ECG during infusion and correct potassium and magnesium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Erythromycin lactobionate with Paroxetine?
MediHelp rates the interaction as moderate. Erythromycin lactobionate and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous erythromycin prolongs the QT interval and can cause torsades de pointes, and peak concentrations are higher with IV use. Paroxetine has a minor QT effect, so combined use may add to the risk, especially with other risk factors.
How serious is the interaction between Erythromycin lactobionate and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antibiotic in patients with QT risk factors. If combined, monitor ECG during infusion and correct potassium and magnesium.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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