Drug interactions
Erythromycin lactobionate + Prednisolone
Severity: Minor
Erythromycin lactobionate and Prednisolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4 and may modestly raise prednisolone exposure. The effect is smaller than with methylprednisolone and is usually manageable.
What this interaction means in plain words
Erythromycin lactobionate and Prednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erythromycin lactobionate belongs to Anti Bacterial; Prednisolone belongs to Endocrine.
Why it happens
CYP3A4 inhibition by erythromycin reduces corticosteroid clearance.
What to do
No routine dose change is needed. Monitor for corticosteroid adverse effects during prolonged co-therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Erythromycin lactobionate with Prednisolone?
MediHelp rates the interaction as minor. Erythromycin lactobionate and Prednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erythromycin inhibits CYP3A4 and may modestly raise prednisolone exposure. The effect is smaller than with methylprednisolone and is usually manageable.
How serious is the interaction between Erythromycin lactobionate and Prednisolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for corticosteroid adverse effects during prolonged co-therapy.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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