Drug interactions
Erythromycin lactobionate + Tadalafil
Severity: Moderate
Erythromycin lactobionate and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin is a moderate CYP3A4 inhibitor and can raise tadalafil exposure. Higher levels may cause hypotension, dizziness, visual disturbance, prolonged erection and other PDE5 inhibitor adverse effects.
What this interaction means in plain words
Erythromycin lactobionate and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin lactobionate belongs to Anti Bacterial; Tadalafil belongs to Genitourinary.
Why it happens
Erythromycin inhibits CYP3A4-mediated metabolism of tadalafil, reducing its clearance.
What to do
Use the lowest effective tadalafil dose, with reduced maximum dosing for erectile dysfunction per labeling, and counsel on hypotension and priapism. Consider a non-CYP3A4-inhibiting antibiotic if the patient has pulmonary hypertension or cardiovascular risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Erythromycin lactobionate with Tadalafil?
MediHelp rates the interaction as moderate. Erythromycin lactobionate and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin is a moderate CYP3A4 inhibitor and can raise tadalafil exposure. Higher levels may cause hypotension, dizziness, visual disturbance, prolonged erection and other PDE5 inhibitor adverse effects.
How serious is the interaction between Erythromycin lactobionate and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective tadalafil dose, with reduced maximum dosing for erectile dysfunction per labeling, and counsel on hypotension and priapism. Consider a non-CYP3A4-inhibiting antibiotic if the patient has pulmonary hypertension or cardiovascular risk.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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