Drug interactions
Erythromycin lactobionate + Telavancin
Severity: Moderate
Erythromycin lactobionate and Telavancin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin and telavancin both prolong the QT interval, so the combination may cause additive prolongation and arrhythmia such as torsades de pointes. IV erythromycin gives high peak concentrations, which heightens the concern.
What this interaction means in plain words
Erythromycin lactobionate and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin lactobionate belongs to Anti Bacterial; Telavancin belongs to Anti Bacterial.
Why it happens
Additive pharmacodynamic QT prolongation, with erythromycin blocking cardiac hERG potassium channels.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor the QTc during therapy, or choose a non-QT-prolonging antibiotic when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telavancin
- Telavancin + Thioridazine Contraindicated
- Adagrasib + Telavancin Major
- Amiodarone + Telavancin Major
- Amisulpride + Telavancin Major
- Anagrelide + Telavancin Major
- Arsenic trioxide + Telavancin Major
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Erythromycin lactobionate with Telavancin?
MediHelp rates the interaction as moderate. Erythromycin lactobionate and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous erythromycin and telavancin both prolong the QT interval, so the combination may cause additive prolongation and arrhythmia such as torsades de pointes. IV erythromycin gives high peak concentrations, which heightens the concern.
How serious is the interaction between Erythromycin lactobionate and Telavancin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor the QTc during therapy, or choose a non-QT-prolonging antibiotic when possible.
What other medicines interact with Telavancin?
MediHelp also lists interactions of Telavancin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Telavancin page.
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