Drug interactions
Erythromycin lactobionate + Triptorelin
Severity: Moderate
Erythromycin lactobionate and Triptorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin produces higher peak levels and is a recognized cause of QT prolongation and torsades de pointes. Triptorelin may add modest QT lengthening, increasing arrhythmia risk in susceptible patients.
What this interaction means in plain words
Erythromycin lactobionate and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin lactobionate belongs to Anti Bacterial; Triptorelin belongs to Endocrine.
Why it happens
Additive QT prolongation; erythromycin blocks hERG potassium channels.
What to do
Prefer a non-QT-prolonging antibiotic in at-risk patients. If used, obtain ECG and correct potassium and magnesium, with telemetry in high-risk cases.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triptorelin
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Erythromycin lactobionate with Triptorelin?
MediHelp rates the interaction as moderate. Erythromycin lactobionate and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous erythromycin produces higher peak levels and is a recognized cause of QT prolongation and torsades de pointes. Triptorelin may add modest QT lengthening, increasing arrhythmia risk in susceptible patients.
How serious is the interaction between Erythromycin lactobionate and Triptorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-QT-prolonging antibiotic in at-risk patients. If used, obtain ECG and correct potassium and magnesium, with telemetry in high-risk cases.
What other medicines interact with Triptorelin?
MediHelp also lists interactions of Triptorelin with, for example, Amisulpride, Arsenic trioxide, Bedaquiline. The full list is on the Triptorelin page.
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