Drug interactions
Escitalopram + Tucatinib
Severity: Minor
Escitalopram and Tucatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a moderate CYP3A inhibitor and also inhibits P-gp. Escitalopram is metabolized by CYP2C19, 3A4, and 2D6, so the effect is likely small. A modest rise in escitalopram levels could increase adverse effects including QT prolongation.
What this interaction means in plain words
Escitalopram and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Escitalopram belongs to Central Nervous System; Tucatinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 by tucatinib may modestly reduce one pathway of escitalopram metabolism.
What to do
No empiric dose change is usually needed. Watch for escitalopram adverse effects such as nausea, somnolence, or palpitations and reduce the dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Escitalopram with Tucatinib?
MediHelp rates the interaction as minor. Escitalopram and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tucatinib is a moderate CYP3A inhibitor and also inhibits P-gp. Escitalopram is metabolized by CYP2C19, 3A4, and 2D6, so the effect is likely small. A modest rise in escitalopram levels could increase adverse effects including QT prolongation.
How serious is the interaction between Escitalopram and Tucatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is usually needed. Watch for escitalopram adverse effects such as nausea, somnolence, or palpitations and reduce the dose if they occur.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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