Drug interactions
Esketamine + Tasimelteon
Severity: Minor
Esketamine and Tasimelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness, and the combination may increase sedation. Tasimelteon has relatively mild sedative effects, so the added risk is likely modest.
What this interaction means in plain words
Esketamine and Tasimelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Esketamine belongs to Central Nervous System; Tasimelteon belongs to Central Nervous System.
Why it happens
Possible additive sedation from esketamine and the melatonin receptor agonist tasimelteon.
What to do
Monitor for excess sedation after esketamine sessions and advise against driving until the next day after sleep.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esketamine
Other interactions of Tasimelteon
Frequently asked questions
Can I take Esketamine with Tasimelteon?
MediHelp rates the interaction as minor. Esketamine and Tasimelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can cause drowsiness, and the combination may increase sedation. Tasimelteon has relatively mild sedative effects, so the added risk is likely modest.
How serious is the interaction between Esketamine and Tasimelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation after esketamine sessions and advise against driving until the next day after sleep.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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