Drug interactions
Enzalutamide + Tasimelteon
Severity: Major
Enzalutamide and Tasimelteon: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A4 inducers can substantially decrease tasimelteon exposure and may result in loss of efficacy in Non-24-Hour Sleep-Wake Disorder.
What this interaction means in plain words
Enzalutamide and Tasimelteon can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Tasimelteon belongs to Central Nervous System.
Why it happens
Enzalutamide induces CYP3A4, which contributes to tasimelteon clearance.
What to do
Avoid the combination; if unavoidable, monitor for loss of circadian entrainment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Tasimelteon
- Carbamazepine + Tasimelteon Major
- Ciprofloxacin + Tasimelteon Major
- Fluvoxamine + Tasimelteon Major
- Methoxsalen + Tasimelteon Major
- Rifampicin + Tasimelteon Major
- Amobarbital + Tasimelteon Moderate
Frequently asked questions
Can I take Enzalutamide with Tasimelteon?
MediHelp rates the interaction as major. Enzalutamide and Tasimelteon can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Strong CYP3A4 inducers can substantially decrease tasimelteon exposure and may result in loss of efficacy in Non-24-Hour Sleep-Wake Disorder.
How serious is the interaction between Enzalutamide and Tasimelteon?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if unavoidable, monitor for loss of circadian entrainment.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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