Drug interactions
Fluvoxamine + Tasimelteon
Severity: Major
Fluvoxamine and Tasimelteon: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine strongly inhibits CYP1A2, a major pathway for tasimelteon clearance, and can raise tasimelteon exposure substantially. This may increase sedation, somnolence and other adverse effects of tasimelteon.
What this interaction means in plain words
Fluvoxamine and Tasimelteon can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluvoxamine belongs to Central Nervous System; Tasimelteon belongs to Central Nervous System.
Why it happens
Fluvoxamine inhibits CYP1A2-mediated metabolism of tasimelteon.
What to do
Avoid the combination; tasimelteon labeling advises against use with strong CYP1A2 inhibitors. If it cannot be avoided, monitor for excess sedation and adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluvoxamine and Tasimelteon, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Tasimelteon
- Carbamazepine + Tasimelteon Major
- Ciprofloxacin + Tasimelteon Major
- Enzalutamide + Tasimelteon Major
- Methoxsalen + Tasimelteon Major
- Rifampicin + Tasimelteon Major
- Amobarbital + Tasimelteon Moderate
Frequently asked questions
Can I take Fluvoxamine with Tasimelteon?
MediHelp rates the interaction as major. Fluvoxamine and Tasimelteon can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluvoxamine strongly inhibits CYP1A2, a major pathway for tasimelteon clearance, and can raise tasimelteon exposure substantially. This may increase sedation, somnolence and other adverse effects of tasimelteon.
How serious is the interaction between Fluvoxamine and Tasimelteon?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; tasimelteon labeling advises against use with strong CYP1A2 inhibitors. If it cannot be avoided, monitor for excess sedation and adverse effects.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
