Drug interactions
Ciprofloxacin + Tasimelteon
Severity: Major
Ciprofloxacin and Tasimelteon: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ciprofloxacin is a strong CYP1A2 inhibitor and tasimelteon is cleared partly by CYP1A2. Exposure to tasimelteon may rise substantially, increasing adverse effects such as somnolence, headache and abnormal dreams.
What this interaction means in plain words
Ciprofloxacin and Tasimelteon can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ciprofloxacin belongs to Anti Bacterial; Tasimelteon belongs to Central Nervous System.
Why it happens
Inhibition of CYP1A2-mediated metabolism of tasimelteon by ciprofloxacin.
What to do
Avoid the combination per tasimelteon labeling and use a non-CYP1A2-inhibiting antibiotic. If unavoidable, monitor for excess sedation and adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Ciprofloxacin + Thioridazine Contraindicated
- Ciprofloxacin + Tizanidine Contraindicated
- Ciprofloxacin + Vandetanib Contraindicated
- Alosetron + Ciprofloxacin Major
Other interactions of Tasimelteon
- Carbamazepine + Tasimelteon Major
- Enzalutamide + Tasimelteon Major
- Fluvoxamine + Tasimelteon Major
- Methoxsalen + Tasimelteon Major
- Rifampicin + Tasimelteon Major
- Amobarbital + Tasimelteon Moderate
Frequently asked questions
Can I take Ciprofloxacin with Tasimelteon?
MediHelp rates the interaction as major. Ciprofloxacin and Tasimelteon can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ciprofloxacin is a strong CYP1A2 inhibitor and tasimelteon is cleared partly by CYP1A2. Exposure to tasimelteon may rise substantially, increasing adverse effects such as somnolence, headache and abnormal dreams.
How serious is the interaction between Ciprofloxacin and Tasimelteon?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination per tasimelteon labeling and use a non-CYP1A2-inhibiting antibiotic. If unavoidable, monitor for excess sedation and adverse effects.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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