Drug interactions
Carbamazepine + Tasimelteon
Severity: Major
Carbamazepine and Tasimelteon: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine, a CYP3A4 inducer, can markedly reduce tasimelteon exposure and efficacy.
What this interaction means in plain words
Carbamazepine and Tasimelteon can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Tasimelteon belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 (and CYP1A2) increases tasimelteon metabolism.
What to do
Avoid coadministration where possible; if combined, monitor for loss of effect.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Carbamazepine and Tasimelteon, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Tasimelteon
- Ciprofloxacin + Tasimelteon Major
- Enzalutamide + Tasimelteon Major
- Fluvoxamine + Tasimelteon Major
- Methoxsalen + Tasimelteon Major
- Rifampicin + Tasimelteon Major
- Amobarbital + Tasimelteon Moderate
Frequently asked questions
Can I take Carbamazepine with Tasimelteon?
MediHelp rates the interaction as major. Carbamazepine and Tasimelteon can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine, a CYP3A4 inducer, can markedly reduce tasimelteon exposure and efficacy.
How serious is the interaction between Carbamazepine and Tasimelteon?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration where possible; if combined, monitor for loss of effect.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
