Drug interactions
Rifampicin + Tasimelteon
Severity: Major
Rifampicin and Tasimelteon: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin markedly reduces tasimelteon exposure, which can result in loss of efficacy for non-24-hour sleep-wake disorder.
What this interaction means in plain words
Rifampicin and Tasimelteon can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Rifampicin belongs to Anti Bacterial; Tasimelteon belongs to Central Nervous System.
Why it happens
Strong CYP3A4 (and CYP1A2) induction by rifampicin increases tasimelteon metabolism.
What to do
Avoid coadministration. If rifampicin is required, monitor for lost response and consider an alternative.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tasimelteon
- Carbamazepine + Tasimelteon Major
- Ciprofloxacin + Tasimelteon Major
- Enzalutamide + Tasimelteon Major
- Fluvoxamine + Tasimelteon Major
- Methoxsalen + Tasimelteon Major
- Amobarbital + Tasimelteon Moderate
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Rifampicin with Tasimelteon?
MediHelp rates the interaction as major. Rifampicin and Tasimelteon can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifampicin markedly reduces tasimelteon exposure, which can result in loss of efficacy for non-24-hour sleep-wake disorder.
How serious is the interaction between Rifampicin and Tasimelteon?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration. If rifampicin is required, monitor for lost response and consider an alternative.
What other medicines interact with Tasimelteon?
MediHelp also lists interactions of Tasimelteon with, for example, Carbamazepine, Ciprofloxacin, Enzalutamide. The full list is on the Tasimelteon page.
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