Drug interactions
Esketamine intranasal + Lisdexamfetamine
Severity: Moderate
Esketamine intranasal and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine transiently raises blood pressure after dosing and lisdexamfetamine also elevates blood pressure and heart rate. The combination may cause larger or more prolonged hypertensive responses. Patients with uncontrolled hypertension or cardiovascular disease are at particular risk.
What this interaction means in plain words
Esketamine intranasal and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pressor effects: NMDA antagonism with sympathetic activation from esketamine plus amphetamine-induced catecholamine release.
What to do
Check blood pressure before and after esketamine dosing. Manage hypertension before treatment and seek medical care for significant or persistent elevations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Esketamine intranasal with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Esketamine intranasal and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine transiently raises blood pressure after dosing and lisdexamfetamine also elevates blood pressure and heart rate. The combination may cause larger or more prolonged hypertensive responses. Patients with uncontrolled hypertension or cardiovascular disease are at particular risk.
How serious is the interaction between Esketamine intranasal and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure before and after esketamine dosing. Manage hypertension before treatment and seek medical care for significant or persistent elevations.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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