Drug interactions
Esketamine intranasal + Metoclopramide
Severity: Moderate
Esketamine intranasal and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine causes sedation, dissociation and blood pressure elevation, and metoclopramide may add to sedation. Nausea is common after esketamine, so combined use is plausible but warrants awareness of additive CNS effects.
What this interaction means in plain words
Esketamine intranasal and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects.
What to do
Monitor sedation and blood pressure during the post-dose observation period. Use the lowest effective metoclopramide dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Frequently asked questions
Can I take Esketamine intranasal with Metoclopramide?
MediHelp rates the interaction as moderate. Esketamine intranasal and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine causes sedation, dissociation and blood pressure elevation, and metoclopramide may add to sedation. Nausea is common after esketamine, so combined use is plausible but warrants awareness of additive CNS effects.
How serious is the interaction between Esketamine intranasal and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure during the post-dose observation period. Use the lowest effective metoclopramide dose.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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