Drug interactions
Esketamine intranasal + Propofol
Severity: Moderate
Esketamine intranasal and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, and esketamine also produces dissociation and may raise blood pressure. Combined use can cause additive sedation and altered cardiovascular responses.
What this interaction means in plain words
Esketamine intranasal and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression combining GABA-A potentiation with NMDA receptor antagonism.
What to do
Titrate propofol to effect with continuous monitoring of sedation, blood pressure and oxygenation. Tell the anesthesia team about recent esketamine dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Esketamine intranasal and Propofol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Propofol
Frequently asked questions
Can I take Esketamine intranasal with Propofol?
MediHelp rates the interaction as moderate. Esketamine intranasal and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, and esketamine also produces dissociation and may raise blood pressure. Combined use can cause additive sedation and altered cardiovascular responses.
How serious is the interaction between Esketamine intranasal and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to effect with continuous monitoring of sedation, blood pressure and oxygenation. Tell the anesthesia team about recent esketamine dosing.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
