Drug interactions
Eslicarbazepine + Hydrocodone
Severity: Moderate
Eslicarbazepine and Hydrocodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine is a weak to moderate CYP3A4 inducer and may reduce hydrocodone levels, diminishing analgesic effect. When eslicarbazepine is withdrawn, hydrocodone exposure may increase.
What this interaction means in plain words
Eslicarbazepine and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eslicarbazepine belongs to Central Nervous System; Hydrocodone belongs to Musculoskeletal.
Why it happens
CYP3A4 induction by eslicarbazepine increases hydrocodone clearance.
What to do
Monitor pain relief and adjust the hydrocodone dose if needed. If eslicarbazepine is stopped, monitor for sedation and respiratory depression and lower the opioid dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Eslicarbazepine with Hydrocodone?
MediHelp rates the interaction as moderate. Eslicarbazepine and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine is a weak to moderate CYP3A4 inducer and may reduce hydrocodone levels, diminishing analgesic effect. When eslicarbazepine is withdrawn, hydrocodone exposure may increase.
How serious is the interaction between Eslicarbazepine and Hydrocodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain relief and adjust the hydrocodone dose if needed. If eslicarbazepine is stopped, monitor for sedation and respiratory depression and lower the opioid dose.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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