Drug interactions
Eslicarbazepine + Imatinib
Severity: Moderate
Eslicarbazepine and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib is metabolized by CYP3A4, and inducers can substantially lower its concentrations and reduce efficacy. Eslicarbazepine is a weaker inducer than classic anticonvulsants but the effect may still matter.
What this interaction means in plain words
Eslicarbazepine and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eslicarbazepine belongs to Central Nervous System; Imatinib belongs to Oncology.
Why it happens
CYP3A4 induction by eslicarbazepine increases imatinib metabolism.
What to do
Prefer a non-inducing antiseizure drug; if combined, monitor hematologic or molecular response and consider imatinib dose increase guided by response or drug levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Eslicarbazepine with Imatinib?
MediHelp rates the interaction as moderate. Eslicarbazepine and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib is metabolized by CYP3A4, and inducers can substantially lower its concentrations and reduce efficacy. Eslicarbazepine is a weaker inducer than classic anticonvulsants but the effect may still matter.
How serious is the interaction between Eslicarbazepine and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing antiseizure drug; if combined, monitor hematologic or molecular response and consider imatinib dose increase guided by response or drug levels.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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