Drug interactions
Eslicarbazepine + Levothyroxine
Severity: Moderate
Eslicarbazepine and Levothyroxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzyme-inducing antiseizure drugs can increase levothyroxine clearance and raise dose requirements, with possible hypothyroidism. Data for eslicarbazepine are limited but this effect is plausible.
What this interaction means in plain words
Eslicarbazepine and Levothyroxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eslicarbazepine belongs to Central Nervous System; Levothyroxine belongs to Endocrine.
Why it happens
Induction of hepatic glucuronidation and metabolism increases levothyroxine clearance.
What to do
Check TSH about 6 to 8 weeks after starting or stopping eslicarbazepine and adjust levothyroxine dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Levothyroxine
Frequently asked questions
Can I take Eslicarbazepine with Levothyroxine?
MediHelp rates the interaction as moderate. Eslicarbazepine and Levothyroxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzyme-inducing antiseizure drugs can increase levothyroxine clearance and raise dose requirements, with possible hypothyroidism. Data for eslicarbazepine are limited but this effect is plausible.
How serious is the interaction between Eslicarbazepine and Levothyroxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check TSH about 6 to 8 weeks after starting or stopping eslicarbazepine and adjust levothyroxine dose as needed.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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