Drug interactions
Eslicarbazepine + Nicardipine
Severity: Moderate
Eslicarbazepine and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine is a weak CYP3A4 inducer and may reduce nicardipine concentrations. Blood pressure control may be diminished.
What this interaction means in plain words
Eslicarbazepine and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eslicarbazepine belongs to Central Nervous System; Nicardipine belongs to Cardiovascular.
Why it happens
Eslicarbazepine induces CYP3A4 metabolism of nicardipine.
What to do
Monitor blood pressure when eslicarbazepine is started or stopped. Increase the nicardipine dose if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Eslicarbazepine with Nicardipine?
MediHelp rates the interaction as moderate. Eslicarbazepine and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine is a weak CYP3A4 inducer and may reduce nicardipine concentrations. Blood pressure control may be diminished.
How serious is the interaction between Eslicarbazepine and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when eslicarbazepine is started or stopped. Increase the nicardipine dose if response is inadequate.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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