Drug interactions
Eslicarbazepine + Quetiapine
Severity: Moderate
Eslicarbazepine and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine is a weak inducer of CYP3A4 and may lower quetiapine concentrations, potentially reducing its antipsychotic or mood-stabilizing effect. The effect is generally less pronounced than with carbamazepine.
What this interaction means in plain words
Eslicarbazepine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eslicarbazepine belongs to Central Nervous System; Quetiapine belongs to Central Nervous System.
Why it happens
Induction of CYP3A4-mediated quetiapine metabolism by eslicarbazepine.
What to do
Monitor clinical response to quetiapine after starting or increasing eslicarbazepine and increase the quetiapine dose if efficacy is lost. Reduce the dose again if eslicarbazepine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Eslicarbazepine with Quetiapine?
MediHelp rates the interaction as moderate. Eslicarbazepine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine is a weak inducer of CYP3A4 and may lower quetiapine concentrations, potentially reducing its antipsychotic or mood-stabilizing effect. The effect is generally less pronounced than with carbamazepine.
How serious is the interaction between Eslicarbazepine and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to quetiapine after starting or increasing eslicarbazepine and increase the quetiapine dose if efficacy is lost. Reduce the dose again if eslicarbazepine is stopped.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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