Drug interactions
Eslicarbazepine + Quizartinib
Severity: Moderate
Eslicarbazepine and Quizartinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine is a weak-to-moderate CYP3A4 inducer and may lower quizartinib exposure. Reduced quizartinib concentrations could compromise its antileukemic efficacy in FLT3-ITD positive AML.
What this interaction means in plain words
Eslicarbazepine and Quizartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eslicarbazepine belongs to Central Nervous System; Quizartinib belongs to Oncology.
Why it happens
Induction of CYP3A4 by eslicarbazepine increases the metabolic clearance of quizartinib, a CYP3A4 substrate.
What to do
Prefer a non-inducing antiseizure drug where possible. If coadministration is needed, monitor leukemia response and consider the ECG and dose guidance in quizartinib labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eslicarbazepine and Quizartinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Quizartinib
- Quizartinib + Thioridazine Contraindicated
- Quizartinib + Ziprasidone Contraindicated
- Alfuzosin + Quizartinib Major
- Amiodarone + Quizartinib Major
- Amitriptyline + Quizartinib Major
- Amobarbital + Quizartinib Major
Frequently asked questions
Can I take Eslicarbazepine with Quizartinib?
MediHelp rates the interaction as moderate. Eslicarbazepine and Quizartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine is a weak-to-moderate CYP3A4 inducer and may lower quizartinib exposure. Reduced quizartinib concentrations could compromise its antileukemic efficacy in FLT3-ITD positive AML.
How serious is the interaction between Eslicarbazepine and Quizartinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing antiseizure drug where possible. If coadministration is needed, monitor leukemia response and consider the ECG and dose guidance in quizartinib labeling.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
