Drug interactions
Eslicarbazepine + Sertraline
Severity: Minor
Eslicarbazepine and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine can inhibit CYP2C19 and also induces CYP3A4, so it may change sertraline exposure unpredictably. Reduced antidepressant effect or altered tolerability may occur. The clinical effect is generally modest.
What this interaction means in plain words
Eslicarbazepine and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eslicarbazepine belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
Eslicarbazepine inhibits CYP2C19 and induces CYP3A4, which may alter sertraline metabolism.
What to do
Monitor for loss of antidepressant response or sertraline adverse effects after starting or stopping eslicarbazepine. Adjust the sertraline dose according to clinical response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Eslicarbazepine with Sertraline?
MediHelp rates the interaction as minor. Eslicarbazepine and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eslicarbazepine can inhibit CYP2C19 and also induces CYP3A4, so it may change sertraline exposure unpredictably. Reduced antidepressant effect or altered tolerability may occur. The clinical effect is generally modest.
How serious is the interaction between Eslicarbazepine and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of antidepressant response or sertraline adverse effects after starting or stopping eslicarbazepine. Adjust the sertraline dose according to clinical response.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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