Drug interactions
Eslicarbazepine + Sufentanil
Severity: Minor
Eslicarbazepine and Sufentanil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is metabolized mainly by CYP3A4. Eslicarbazepine may weakly induce this enzyme and reduce sufentanil exposure, potentially shortening or weakening analgesia.
What this interaction means in plain words
Eslicarbazepine and Sufentanil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eslicarbazepine belongs to Central Nervous System; Sufentanil belongs to Musculoskeletal.
Why it happens
Weak CYP3A4 induction by eslicarbazepine increases sufentanil clearance.
What to do
Titrate sufentanil to analgesic effect and watch for inadequate pain control. Remain alert to opioid withdrawal or toxicity if eslicarbazepine is stopped or started during chronic opioid use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Eslicarbazepine with Sufentanil?
MediHelp rates the interaction as minor. Eslicarbazepine and Sufentanil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sufentanil is metabolized mainly by CYP3A4. Eslicarbazepine may weakly induce this enzyme and reduce sufentanil exposure, potentially shortening or weakening analgesia.
How serious is the interaction between Eslicarbazepine and Sufentanil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate sufentanil to analgesic effect and watch for inadequate pain control. Remain alert to opioid withdrawal or toxicity if eslicarbazepine is stopped or started during chronic opioid use.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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