Drug interactions
Eslicarbazepine + Tivozanib
Severity: Moderate
Eslicarbazepine and Tivozanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tivozanib is cleared partly by CYP3A4, and eslicarbazepine can induce this enzyme. Lower tivozanib exposure may reduce antitumor efficacy.
What this interaction means in plain words
Eslicarbazepine and Tivozanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eslicarbazepine belongs to Central Nervous System; Tivozanib belongs to Oncology.
Why it happens
Eslicarbazepine induces CYP3A4, increasing the metabolic clearance of tivozanib.
What to do
Monitor tumor response and consider a non-inducing antiseizure drug where possible. Tivozanib labeling advises avoiding strong CYP3A4 inducers, so reassess the need for the combination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Tivozanib
- Amobarbital + Tivozanib Major
- Carbamazepine + Tivozanib Major
- Phenytoin + Tivozanib Major
- Secobarbital + Tivozanib Major
- Apalutamide + Tivozanib Moderate
- Bosentan + Tivozanib Moderate
Frequently asked questions
Can I take Eslicarbazepine with Tivozanib?
MediHelp rates the interaction as moderate. Eslicarbazepine and Tivozanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tivozanib is cleared partly by CYP3A4, and eslicarbazepine can induce this enzyme. Lower tivozanib exposure may reduce antitumor efficacy.
How serious is the interaction between Eslicarbazepine and Tivozanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response and consider a non-inducing antiseizure drug where possible. Tivozanib labeling advises avoiding strong CYP3A4 inducers, so reassess the need for the combination.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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