Drug interactions
Eslicarbazepine + Vonoprazan
Severity: Moderate
Eslicarbazepine and Vonoprazan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vonoprazan is metabolized by CYP3A4 among other enzymes, so inducers may lower its exposure. Acid suppression may be reduced.
What this interaction means in plain words
Eslicarbazepine and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eslicarbazepine belongs to Central Nervous System; Vonoprazan belongs to Gastrointestinal Tract.
Why it happens
Eslicarbazepine induces CYP3A4, increasing vonoprazan clearance.
What to do
Monitor symptom control and healing outcomes. Consider a higher dose or alternative acid suppression if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Vonoprazan
- Amobarbital + Vonoprazan Major
- Apalutamide + Vonoprazan Major
- Atazanavir + Vonoprazan Major
- Carbamazepine + Vonoprazan Major
- Erlotinib + Vonoprazan Major
- Phenytoin + Vonoprazan Major
Frequently asked questions
Can I take Eslicarbazepine with Vonoprazan?
MediHelp rates the interaction as moderate. Eslicarbazepine and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vonoprazan is metabolized by CYP3A4 among other enzymes, so inducers may lower its exposure. Acid suppression may be reduced.
How serious is the interaction between Eslicarbazepine and Vonoprazan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control and healing outcomes. Consider a higher dose or alternative acid suppression if response is inadequate.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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