Drug interactions
Eslicarbazepine + Warfarin
Severity: Moderate
Eslicarbazepine and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine may lower warfarin exposure and INR, risking reduced anticoagulation and thrombosis. The effect is generally modest, but dose changes can be needed.
What this interaction means in plain words
Eslicarbazepine and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eslicarbazepine belongs to Central Nervous System; Warfarin belongs to Cardiovascular.
Why it happens
Eslicarbazepine weakly induces CYP3A4 (and possibly other enzymes), increasing warfarin metabolism; it may also inhibit CYP2C19.
What to do
Check INR more often after starting, changing the dose of, or stopping eslicarbazepine, and adjust the warfarin dose to keep INR in range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Eslicarbazepine with Warfarin?
MediHelp rates the interaction as moderate. Eslicarbazepine and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine may lower warfarin exposure and INR, risking reduced anticoagulation and thrombosis. The effect is generally modest, but dose changes can be needed.
How serious is the interaction between Eslicarbazepine and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR more often after starting, changing the dose of, or stopping eslicarbazepine, and adjust the warfarin dose to keep INR in range.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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