Drug interactions
Esmolol + Felodipine
Severity: Moderate
Esmolol and Felodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, and felodipine is a dihydropyridine with little direct effect on nodal conduction. Combined use may cause additive hypotension, sometimes with reflex tachycardia partly blunted by esmolol.
What this interaction means in plain words
Esmolol and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esmolol belongs to Cardiovascular; Felodipine belongs to Cardiovascular.
Why it happens
Additive vasodilation from calcium channel blockade and reduced cardiac output from beta-blockade.
What to do
Monitor blood pressure and heart rate and adjust the esmolol infusion rate as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Esmolol with Felodipine?
MediHelp rates the interaction as moderate. Esmolol and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, and felodipine is a dihydropyridine with little direct effect on nodal conduction. Combined use may cause additive hypotension, sometimes with reflex tachycardia partly blunted by esmolol.
How serious is the interaction between Esmolol and Felodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and adjust the esmolol infusion rate as required.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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