Drug interactions
Esmolol + Indomethacin
Severity: Minor
Esmolol and Indomethacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prolonged NSAID use can blunt the antihypertensive effect of beta-blockers. Esmolol is used short-term, so the clinical effect is likely small.
What this interaction means in plain words
Esmolol and Indomethacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Esmolol belongs to Cardiovascular; Indomethacin belongs to Musculoskeletal.
Why it happens
NSAID inhibition of vasodilatory prostaglandins causes sodium and water retention, opposing blood pressure lowering.
What to do
Monitor blood pressure and heart rate if indomethacin is used alongside esmolol; no dose change is usually needed for short-term use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Frequently asked questions
Can I take Esmolol with Indomethacin?
MediHelp rates the interaction as minor. Esmolol and Indomethacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Prolonged NSAID use can blunt the antihypertensive effect of beta-blockers. Esmolol is used short-term, so the clinical effect is likely small.
How serious is the interaction between Esmolol and Indomethacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate if indomethacin is used alongside esmolol; no dose change is usually needed for short-term use.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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