Drug interactions
Esmolol + Isoproterenol
Severity: Moderate
Esmolol and Isoproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esmolol antagonizes the beta-adrenergic effects of isoproterenol, reducing its effect on heart rate, contractility and bronchodilation. Isoproterenol's therapeutic effect may be lost.
What this interaction means in plain words
Esmolol and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esmolol belongs to Cardiovascular; Isoproterenol belongs to Respiratory.
Why it happens
Competitive beta-adrenergic receptor antagonism.
What to do
Avoid combining unless intended; if both are required, monitor heart rate, blood pressure and response, adjusting doses accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Other interactions of Isoproterenol
Frequently asked questions
Can I take Esmolol with Isoproterenol?
MediHelp rates the interaction as moderate. Esmolol and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esmolol antagonizes the beta-adrenergic effects of isoproterenol, reducing its effect on heart rate, contractility and bronchodilation. Isoproterenol's therapeutic effect may be lost.
How serious is the interaction between Esmolol and Isoproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining unless intended; if both are required, monitor heart rate, blood pressure and response, adjusting doses accordingly.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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