Drug interactions
Esmolol + Ketoprofen
Severity: Minor
Esmolol and Ketoprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prolonged NSAID use can reduce the antihypertensive effect of beta-blockers. Esmolol is used short-term in acute settings, so the clinical impact is likely small.
What this interaction means in plain words
Esmolol and Ketoprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Esmolol belongs to Cardiovascular; Ketoprofen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of vasodilatory prostaglandins with sodium and fluid retention opposes blood pressure lowering.
What to do
Monitor blood pressure if ketoprofen is used regularly alongside esmolol; no routine dose change is needed for short-term use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Frequently asked questions
Can I take Esmolol with Ketoprofen?
MediHelp rates the interaction as minor. Esmolol and Ketoprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Prolonged NSAID use can reduce the antihypertensive effect of beta-blockers. Esmolol is used short-term in acute settings, so the clinical impact is likely small.
How serious is the interaction between Esmolol and Ketoprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if ketoprofen is used regularly alongside esmolol; no routine dose change is needed for short-term use.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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