Drug interactions
Esmolol + Nadolol
Severity: Moderate
Esmolol and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nadolol is a long-acting non-selective beta-blocker, and adding esmolol duplicates beta-blockade. This increases the risk of bradycardia, hypotension and AV block.
What this interaction means in plain words
Esmolol and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esmolol belongs to Cardiovascular; Nadolol belongs to Cardiovascular.
Why it happens
Additive beta-adrenergic receptor blockade.
What to do
Use a reduced esmolol dose and titrate with continuous heart rate, blood pressure and ECG monitoring. Stop the esmolol infusion if bradycardia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Other interactions of Nadolol
Frequently asked questions
Can I take Esmolol with Nadolol?
MediHelp rates the interaction as moderate. Esmolol and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nadolol is a long-acting non-selective beta-blocker, and adding esmolol duplicates beta-blockade. This increases the risk of bradycardia, hypotension and AV block.
How serious is the interaction between Esmolol and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a reduced esmolol dose and titrate with continuous heart rate, blood pressure and ECG monitoring. Stop the esmolol infusion if bradycardia or hypotension develops.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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