Drug interactions
Esmolol + Nicardipine
Severity: Moderate
Esmolol and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esmolol and nicardipine both lower blood pressure, and the combination is used in perioperative and acute settings. Hypotension can occur, and nicardipine's reflex tachycardia is blunted by esmolol.
What this interaction means in plain words
Esmolol and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esmolol belongs to Cardiovascular; Nicardipine belongs to Cardiovascular.
Why it happens
Additive hypotension from dihydropyridine vasodilation and beta-blocker reduction in cardiac output.
What to do
Monitor blood pressure and heart rate continuously and titrate each drug to effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Other interactions of Nicardipine
Frequently asked questions
Can I take Esmolol with Nicardipine?
MediHelp rates the interaction as moderate. Esmolol and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esmolol and nicardipine both lower blood pressure, and the combination is used in perioperative and acute settings. Hypotension can occur, and nicardipine's reflex tachycardia is blunted by esmolol.
How serious is the interaction between Esmolol and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate continuously and titrate each drug to effect.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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