Drug interactions
Esmolol + Nimodipine
Severity: Moderate
Esmolol and Nimodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esmolol and nimodipine both lower blood pressure, so together they can cause excessive hypotension. This matters particularly in subarachnoid hemorrhage, where cerebral perfusion pressure must be maintained.
What this interaction means in plain words
Esmolol and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esmolol belongs to Cardiovascular; Nimodipine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects of beta-1 blockade and calcium channel mediated vasodilation.
What to do
Monitor blood pressure and heart rate continuously and titrate esmolol to avoid hypotension. Reduce or hold either drug if blood pressure falls below the target range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Frequently asked questions
Can I take Esmolol with Nimodipine?
MediHelp rates the interaction as moderate. Esmolol and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esmolol and nimodipine both lower blood pressure, so together they can cause excessive hypotension. This matters particularly in subarachnoid hemorrhage, where cerebral perfusion pressure must be maintained.
How serious is the interaction between Esmolol and Nimodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate continuously and titrate esmolol to avoid hypotension. Reduce or hold either drug if blood pressure falls below the target range.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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