Drug interactions
Esmolol + Pilocarpine
Severity: Moderate
Esmolol and Pilocarpine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic pilocarpine can slow heart rate and conduction through muscarinic stimulation, adding to the effects of esmolol. Clinically important effects are mainly a concern with oral pilocarpine in patients with conduction disease.
What this interaction means in plain words
Esmolol and Pilocarpine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esmolol belongs to Cardiovascular; Pilocarpine belongs to Miscellaneous.
Why it happens
Additive cardiac slowing from muscarinic agonism and beta-1 blockade.
What to do
Monitor heart rate and ECG in patients with bradycardia or conduction disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Other interactions of Pilocarpine
- Amitriptyline + Pilocarpine Moderate
- Atenolol-chlorthalidone + Pilocarpine Moderate
- Atenolol + Pilocarpine Moderate
- Atropine + Pilocarpine Moderate
- Betaxolol + Pilocarpine Moderate
- Bethanechol + Pilocarpine Moderate
Frequently asked questions
Can I take Esmolol with Pilocarpine?
MediHelp rates the interaction as moderate. Esmolol and Pilocarpine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic pilocarpine can slow heart rate and conduction through muscarinic stimulation, adding to the effects of esmolol. Clinically important effects are mainly a concern with oral pilocarpine in patients with conduction disease.
How serious is the interaction between Esmolol and Pilocarpine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG in patients with bradycardia or conduction disease.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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