Drug interactions
Esmolol + Secobarbital
Severity: Minor
Esmolol and Secobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes and can lower exposure to some beta-blockers. Esmolol is cleared by red blood cell esterases and not by CYP enzymes, and has a very short half-life, so a meaningful interaction is not expected.
What this interaction means in plain words
Esmolol and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Esmolol belongs to Cardiovascular; Secobarbital belongs to Central Nervous System.
Why it happens
Enzyme induction by secobarbital does not affect esmolol, which is hydrolyzed by erythrocyte esterases.
What to do
No dose adjustment is needed. Titrate esmolol to clinical response as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Esmolol with Secobarbital?
MediHelp rates the interaction as minor. Esmolol and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates induce hepatic enzymes and can lower exposure to some beta-blockers. Esmolol is cleared by red blood cell esterases and not by CYP enzymes, and has a very short half-life, so a meaningful interaction is not expected.
How serious is the interaction between Esmolol and Secobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Titrate esmolol to clinical response as usual.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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