Drug interactions
Esmolol + Sulindac
Severity: Minor
Esmolol and Sulindac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may diminish the antihypertensive effect of beta-blockers, though esmolol is used short-term in acute settings so the practical effect is limited. Blood pressure may be less well controlled during prolonged NSAID exposure.
What this interaction means in plain words
Esmolol and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Esmolol belongs to Cardiovascular; Sulindac belongs to Musculoskeletal.
Why it happens
NSAID inhibition of vasodilatory prostaglandins causes sodium retention and opposes beta-blocker effects.
What to do
Monitor blood pressure and heart rate response to esmolol and titrate the infusion as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Frequently asked questions
Can I take Esmolol with Sulindac?
MediHelp rates the interaction as minor. Esmolol and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs may diminish the antihypertensive effect of beta-blockers, though esmolol is used short-term in acute settings so the practical effect is limited. Blood pressure may be less well controlled during prolonged NSAID exposure.
How serious is the interaction between Esmolol and Sulindac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate response to esmolol and titrate the infusion as needed.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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