Drug interactions
Esmolol + Tolfenamic acid
Severity: Minor
Esmolol and Tolfenamic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the antihypertensive effect of beta-blockers through sodium and fluid retention and reduced prostaglandin synthesis. The effect is mainly with sustained NSAID use and is less relevant to short-term esmolol infusion.
What this interaction means in plain words
Esmolol and Tolfenamic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Esmolol belongs to Cardiovascular; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of prostaglandin synthesis causes sodium and water retention and opposes antihypertensive action.
What to do
Monitor blood pressure if NSAID use is prolonged. Consider the lowest effective NSAID dose or a non-NSAID analgesic.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Esmolol with Tolfenamic acid?
MediHelp rates the interaction as minor. Esmolol and Tolfenamic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs can blunt the antihypertensive effect of beta-blockers through sodium and fluid retention and reduced prostaglandin synthesis. The effect is mainly with sustained NSAID use and is less relevant to short-term esmolol infusion.
How serious is the interaction between Esmolol and Tolfenamic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if NSAID use is prolonged. Consider the lowest effective NSAID dose or a non-NSAID analgesic.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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