Drug interactions
Esomeprazole + Fluvastatin
Severity: Minor
Esomeprazole and Fluvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esomeprazole is a weak inhibitor of CYP2C19 and is not a clinically meaningful CYP2C9 inhibitor, so any rise in fluvastatin exposure is unlikely to matter. No clinically significant interaction has been established.
What this interaction means in plain words
Esomeprazole and Fluvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Esomeprazole belongs to Gastrointestinal Tract; Fluvastatin belongs to Cardiovascular.
Why it happens
Theoretical weak CYP2C9 inhibition by esomeprazole; not established as clinically relevant.
What to do
No dose adjustment is needed; report muscle symptoms if they occur during routine statin monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Frequently asked questions
Can I take Esomeprazole with Fluvastatin?
MediHelp rates the interaction as minor. Esomeprazole and Fluvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Esomeprazole is a weak inhibitor of CYP2C19 and is not a clinically meaningful CYP2C9 inhibitor, so any rise in fluvastatin exposure is unlikely to matter. No clinically significant interaction has been established.
How serious is the interaction between Esomeprazole and Fluvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; report muscle symptoms if they occur during routine statin monitoring.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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