Drug interactions
Esomeprazole + Iron
Severity: Moderate
Esomeprazole and Iron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esomeprazole reduces gastric acid and can lower absorption of oral iron. With long-term use this may lead to a reduced response to iron therapy.
What this interaction means in plain words
Esomeprazole and Iron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esomeprazole belongs to Gastrointestinal Tract; Iron belongs to Gastrointestinal Tract.
Why it happens
Acid suppression raises gastric pH and decreases iron solubility and reduction to the ferrous form.
What to do
Monitor hemoglobin and ferritin, and consider intravenous iron or the lowest effective PPI dose if response is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Iron
- Acetohydroxamic acid + Iron Moderate
- Aluminum hydroxide + Iron Moderate
- Baloxavir marboxil + Iron Moderate
- Calcium acetate + Iron Moderate
- Calcium carbonate + Iron Moderate
- Calcium citrate + Iron Moderate
Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Frequently asked questions
Can I take Esomeprazole with Iron?
MediHelp rates the interaction as moderate. Esomeprazole and Iron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esomeprazole reduces gastric acid and can lower absorption of oral iron. With long-term use this may lead to a reduced response to iron therapy.
How serious is the interaction between Esomeprazole and Iron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and ferritin, and consider intravenous iron or the lowest effective PPI dose if response is poor.
What other medicines interact with Iron?
MediHelp also lists interactions of Iron with, for example, Acetohydroxamic acid, Aluminum hydroxide, Baloxavir marboxil. The full list is on the Iron page.
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